Study the Relation between Vitamin D with Interleukins 12, 17 and 23 in Rheumatoid Arthritis Iraqi Women.

Abstract

Rheumatoid arthritis(RA) which establishes as Continuous & progressive joint devastation is a public prolonged autoimmune illness with inflammation which leads to pain, stiffness, and the final result functional disability. The objective of this cross sectional study was to explore the function of serum Vitamin D (Vit D), interleukin (IL)12, IL-17 & IL-23 in Iraqi Women with RA, and to evaluate their relationship with disease action & joint severity.

 

The work involved 42 RA Iraqi women patients and 42 healthy control matched by age and sex. Serum concentrations of VIT. D, IL-12, IL-17, IL-23 and Anti-cyclic citrullinated peptide (ACCP) were estimated via commercially available ELISA kit. Serum levels of Vit. D, IL-12, IL-17, IL-23 and ACCP were importantly greater (P<0.001) in RA cases as related to healthy control. There was an important negative link between Vit. D and IL-12, IL-17 and IL-23, while an important positive link between IL-12 with IL-23, IL-17 with IL-23 and ACCP. Substantial sign shows that RA cases have small concentration of Vit. D. The proinflammatory grade arising in RA is considered through stimulation of inflammatory cells, augmented concentrations of inflammatory intermediaries & the attendance of autoantibodies, compatible in prompting endothelial dysfunction.