Synthesis, Characterization and Bacterial Activity Study of Some Mixed Ligand Cadmium(II) Complexes with Diclofenac and N-donor Ligands

Abstract

New complexes of Cd(II) were prepared by reaction of one mole equivalent of cadmium chloride with two moles equivalent of sodium diclofenac and suitable moles of one of the following ligands (1,10-phenanthroline (Phen), bipyridine (bipy), 2-aminopyridine (2-apy), 3-aminopyridine (3-apy), 4-aminopyridine (4-apy) or cyanoguanidine (cg)). The obtained results indicated that the diclofenac behaved as a monodentate ligand coordinated to cadmium ion through oxygen atom of the carboxyl group, while (bipy and phen) behaved as bidentate ligands, the substituted aminopyridine and cyanoguanidine behaved as monodentate ligands. The prepared complexes have tetrahedral geometry. The prepared complexes were characterized by conductivity measurements, element analysis CHN, also by infrared and $\text{}^1\text{H-NMR}$ spectroscopy. Some of the prepared complexes showed biological activity against two bacterial types' staphylcocas aureus, pseudomonas aeruginosa in comparison with the antibiotic gentamycin.