Spectrophotometric determination of Domperidone and Phenobarbital in pure forms and in the pharmaceutical preparations by NQS reagent

Abstract

“A sensitive, rapid and economical” spectrophotometric methods for estimation of two drugs; Domperidone (Dom) and Phenobarbital (Phe), by “Sodium 1,2-naphthoquine- 4-sulfonate (NQS)” as reagent in an alkaline medium. These methods are summarized on the forming of “color products” among these drugs and the chromogenic reagent (NQS). Orange colored product formed at (pH 13) and $\lambda_{\text{max}}$ 460 nm for (Dom), and orange colored product at (pH 13.5) and $\lambda_{\text{max}}$ 460 nm for (Phe). Beer's Law is obeyed in a concentrations range of (20-80 $\mu\text{g/ml}$), (10-90 $\mu\text{g/ml}$), with molar absorptivity ($6.644\times10^3\text{ L/mol.cm}$), ($3.019\times10^3\text{ L/mol.cm}$), and correlation coefficient 0.9999, 0.9991, respectively, The detection limit were (0.463 $\mu\text{g/ml}$, 2.022 $\mu\text{g/ml}$), respectively. The suggested methods were prosperity implement to the estimation of “these drugs” in pure forms and in their pharmaceutical formulations as (Tablets).