Importance of Growth hormone (GH) and insulin like growth factor-1(IGF-1)-1in diabetic patients

Abstract

This study aimed to determine Growth hormone (GH), Insulin like growth factor- 1( IGF-1), Fasting blood glucose (FBG) and Body mass index (BMI) levels. also to find relations between GH and IGF-1, in addition to GH and IGF-1 with BMI in diabetic patients. A current study included(60) patients (21male:39female) with age (13-74)years, in addition to (30) controls. BMI calculated by weight and length measurement, FBG tested by spectrophotometer and hormones by ELISA technique. Statistical analysis performed by Danken and Minitab ver. 2017. This study revealed a significant decrease (P$\le$0.05) in GH concentration in patients (121.2 $\pm$29.1) ML.U/ml than control (150$\pm$33) ML.U/ml , female patient than control and in (15-30) and (46-60) years than other age groups .There are significant deference (P$\le$0.05) in IGF-1among different age groups , also between male and female patients in IGF-1 in (15-30) years, and between male patients and control in (15-30)years . There is significant increase (P$\le$0.05) in FBG in patients (192.7 $\pm$45.2) mg/100ml than control (112.4 $\pm$11.8) mg/100ml. The obesity reported in patients: BMI (30.29 $\pm$6.26)kg/m2 versus control (28.48 $\pm$5.61)kg/m2 but this difference not significant statistically (P$\ge$0.05). There are positive relation between GH and IGF-1 (P:0.5, R: 0.283) but negative relations between GH and BMI (P:0.026, R: -0.29) and between IGF-1and BMI (P:0.702, R:-0.051) in patients. The current study concluded a significant decrease in GH but increase of IGF-1 but not significant. The age affects each GH and IGF-1. There are positive relation between GH and IGF-1 but negative relation of BMI with GH and IGF-1.