Comparsion study of the effect of certain antihypertensive drugs on testosterone and estrogen hormones concentrations in white male rats

Abstract

This study was conducted in the animal house of the department of biology – college of education for women – University of Tikrit to evaluate and compare the effect of certain antihypertensive drugs on testosterone and estrogen hormones in male rats. 50 male rats aged 4-6 months were used, with weights from 250-400 g distributed into five groups, 10 for each group (control, Amlodipine, 0.428mg Valsartan 0.68mg, Captopril 0.214mg, and Atenolol 0.42mg) twice daily for 60 days. The samples were analyzed in the COBAS e411 from Roche Hitachi according to the manufacturer, The results of the study showed significant differences ($P \le 0.01$) decreased the level of testosterone for both amlodipine and atenolol along the duration of the experiment compared with control group, While the results of both valsartan and captopril showed a rise in the level of testosterone, While the level of estrogen increased at significant differences ($P \le 0.01$) in all treatment of the totals drugs on the period of the experiment compared with the control group. The study suggested that treatment with amlodipine and atenolol may cause abnormalities in the sex hormones of the male reproductive system, which indicate the inhibition of testosterone.