Anti-bacterial, Anti-fungi Activity Evaluation and Computational Study of Co(II) and Cu(II)-Dithiocarbamate Complexes

Abstract

[Co(κ²-Et₂DT)₂] (1), [Cu(κ²-Et₂DT)₂] (2), [Co(κ²-PyDT)₂] (3), [Cu(κ²-PyDT)₂] (4), [Co(κ²-PipDT)₂] (5) and [Cu(κ²-PipDT)₂] (6) (Where Et₂DT = diethyl dithiocarbamate; PyDT= pyrrolidine dithiocarbamate; PipDT = piperidine dithiocarbamate) were synthesized and characterized. The dithiocarbamate (DTC) behave as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with Cu(II) ion. The dithiocarbamate complexes displayed good activity against the pathogen microbial species (bacteria and fungi). The results showed the Cu-dithiocarbamate complexes are more active against all the tested bacteria then the Co-dithiocarbamate complexes and the DTC-compounds displayed the highest inhibition region against E. coli bacteria. Also, The [Cu(κ²-PipDT)₂](6) complex show a highest activity against all fungi types compared with other complexes, also we used the Density Functional Theory (DFT) to characterize the stability of the prepared complexes.