Synthesis and Identification of New Derivatives of Bis-1,3-Oxazepene and 1,3-Diazepine and Assess the Biological and Laser Efficacy for Them

Abstract

In this study, new schiff bases [A₁-A₂] compounds were prepared by the reaction of terephthalaldehyde with different substituted aniline (4-methoxyaniline and 4-methylaniline) in absolute ethanol, then schiff bases were converted into 1,3-oxazepine derivatives [A₃-A₄] by reacted with 3-bromophthalic anhydride in dry benzene.1,3-Oxazepine derivatives were converted into 1,3-diazepine derivatives [A₅-A₆] through reaction with aniline. The prepared compounds were characterized by physical properties, UV-Vis, FT-IR and ¹H-NMR spectral and C.H.N analysis. TLC checked the purity for these compounds. The antibacterial activities were studied against different kinds of bacteria, namely Eschershia coli and Klebislla Pneumonia Gram (-) ve, Staphylococcus aureus and Staphylococcus epidermidis Gram (+) ve. In addition, evaluation of laser efficacy is showed for the compounds [A₁-A₆] were radiated by laser for (10, 20, 30) seconds. It was found that all the prepared compounds did not have an effect and did not decompose or polymerize when color and the melting point were measured. The stereoisomers of the prepared compounds [A₁-A₆] were also studied at the lowest layer level using the Chem Draw Professional 16.0 program. Heat of formation of the prepared compounds [A₁-A₆] were also studied using the Chem3D 16.0 program.