Histological changes in breast Cancer patients and the physiological role of Leptin and Interleukin-6 in blood serum

Abstract

The current study included two aspects, which were histological physiological. (75) blood samples from women with breast cancer, in addition to 15 blood samples for healthy women as control were grouped. In addition to collecting tissue biopsy from the mammary glands of some women whose blood samples were drawn Included were also. Women diagnosed with breast cancer, ages ranged between 38-68 years. The study was conducted from 1 May 2019 to 2 October 2019. The results of microscopic examination showed the presence of invasive breast cancer, there were types of breast cancer, including infiltrative carcinoma, and metaplastic carcinoma. Another types of gland cancer were medullary carcinoma, and invasive Ductal carcinoma, which is breast cancer the musinaise type. The results also revealed the presence of ductal carcinoma in situ DCIS (the sold type). The results also showed the spread of cancerous Paget disease to the dermal layer of the skin. The physiological results showed hematological changes characterized by a high level of Leptin hormone (P≤0.01) in the blood of women with breast cancer group 3, compared with the control group, while there was a significant increase (P≤0.05) in women with a concentration of hormone (P≤0.05) in injuries in groups 2 and 5, compared with the control group, and no significant changes occurred in groups 4 and 6 compared to the control group. Also significant increase (P≤ 0.01) in the concentration of interleukin-6 group of women with breast cancer group 6 compared to the control group, while the group 2 and 3 showed a significant increase (P≤ 0.05) compared to the control group, while group 4 recorded significant decrease (P≤0.05) in interleukin-6 concentration compared to control group. From the results of the current study, Conclusion can be made that, breast cancer has severe negative effects on the histological composition of breast tissue, which negatively affects the functional role of the Leptin hormone and interleukin-6 in the blood serum.