Inflammatory and metabolic synergy Investigating the role of IL-33 with the adipokines resistin and visfatin in promoting the growth and invasion of breast cancer cells.

Abstract

The present study was designed to assess and evaluate specificimmunological (IL-33) and physiological (Resistin and Visfatin) parameters among a selected cohort of Iraqi women diagnosed with breast cancer in Baghdad city. A total of 60 whole blood samples were collected and categorized into two groups: the first group consisted of healthy individuals serving as the control group, while the second group comprised clinically confirmed breast cancer patients. The findings of the current study demonstrated highly significant elevations (P ≤ 0.05) in the concentration levels of the pro-inflammatory cytokine IL-33 in the patient group compared with the control group. Moreover, the results revealed a marked and statistically significant increase in both Resistin and Visfatin molecules among breast cancer patients. These findings indicate that elevated levels of specific biomarkers may play a key role in the immuno-metabolic regulation underlying breast cancer development and progression. The study suggests that these biomarkers influence tumor growth, immune response, and the tumor microenvironment. Furthermore, they may serve as valuable diagnostic tools for early detection and as prognostic indicators to predict disease severity, treatment response, and risk of recurrence. Overall, these results highlight their potential application in personalized medicine strategies for breast cancer management..